Spontaneous lymphomas in mice genetically selected for high or low phytohemagglutinin responsiveness.
J Natl Cancer Inst
; 75(6): 1083-90, 1985 Dec.
Article
em En
| MEDLINE
| ID: mdl-3877838
ABSTRACT
Biozzi mice selected for high (Hi) or low (Lo) responsiveness to phytohemagglutinin (PHA) have been followed for their entire life-span to examine their pathology at death. Spontaneous lymphomas were found to exhibit higher incidence and faster development in Lo/PHA than in Hi/PHA females, whereas a similar difference between the two lines did not attain the level of statistical significance in male mice. The incidence of solid tumors was higher in Lo/PHA than in Hi/PHA males but the same in females of the two lines, yet the probability of dying from solid tumors was slightly increased in Lo/PHA mice of both sexes. All these results indicate that T-cell-mediated immunity influences mainly the spontaneous incidence of lymphomas and, to a lesser degree, the appearance of other solid tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fito-Hemaglutininas
/
Doenças dos Roedores
/
Linfócitos T
/
Linfoma
/
Camundongos
Limite:
Animals
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1985
Tipo de documento:
Article