Programmably engineered stochastic RNA nanowalker for ultrasensitive miRNA detection.

Zhu, Dan; Zhao, Dongxia; Hu, Yang; Wei, Tianhui; Su, Tong; Su, Shao; Chao, Jie; Wang, Lianhui

Zhu, Dan; Zhao, Dongxia; Hu, Yang; Wei, Tianhui; Su, Tong; Su, Shao; Chao, Jie; Wang, Lianhui.

Afiliação

Zhu D; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
Zhao D; State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Hu Y; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
Wei T; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
Su T; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
Su S; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
Chao J; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.
Wang L; State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. iamlhwang@njupt.edu.cn.

Chem Commun (Camb) ; 60(48): 6142-6145, 2024 Jun 11.

Article em En | MEDLINE | ID: mdl-38804211

ABSTRACT

ABSTRACT

A programmably engineered stochastic RNA nanowalker powered by duplex-specific nuclease (DSN) is developed. By utilizing poly-adenine-based spherical nucleic acids (polyA-SNA) to accurately regulate the densities of DNA tracks, the nanowalker showcases its capability to identify miRNA-21, miRNA-486, and miRNA-155 with quick kinetics and attomolar sensitivity, positioning it as a promising option for cancer clinical surveillance.

Assuntos

MicroRNAs; MicroRNAs/análise; Humanos; Nanoestruturas/química; Poli A/química; DNA/química; Processos Estocásticos; Técnicas Biossensoriais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs Limite: Humans Idioma: En Revista: Chem Commun (Camb) Assunto da revista: QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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