Long-term efficacy and safety of rituximab in the treatment of neuromyelitis Optica Spectrum disorder.
Mult Scler J Exp Transl Clin
; 10(2): 20552173241257876, 2024.
Article
em En
| MEDLINE
| ID: mdl-38807849
ABSTRACT
Background:
Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune, inflammatory astrocytopathy. Rituximab for B-cell suppression is a common treatment for NMOSD; however, large-scale randomised controlled trials are lacking.Objective:
Evaluate long-term efficacy and safety of rituximab for NMOSD.Methods:
Retrospective observational study of patients with NMOSD treated with rituximab. Annualised relapse rates (ARRs) before and during rituximab treatment were evaluated; Modified Rankin Scores (mRS) were measured as a marker of disability.Results:
In total, 37 patients were included 27 aquaporin-4-IgG-seropositive and 10 seronegative NMOSD. The predominant rituximab dosing regimen was an initial 1000 mg, split over two 500 mg infusions, two weeks apart, followed by single 500 mg doses. Over a median follow-up of 54 months, ARR for the whole cohort was 0.136 (95% CI 0.088-0.201), significantly lower than the pretreatment ARR of 0.366 (95% CI 0.271-0.483, p < 0.001). There was a significant reduction in ARR for the seropositive subgroup, but not seronegative. Significant improvement in mRS was seen post-treatment. Infections were reported in 32% of patients during follow-up; most were mild.Conclusion:
Rituximab, at doses lower than traditionally used, may be an efficacious therapy for NMOSD, with a favourable safety profile.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mult Scler J Exp Transl Clin
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Austrália