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Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA.
Masano, Yusuke; Saegusa, Chika; Ishikawa, Mitsuru; Matsunaga, Tatsuo; Okano, Hideyuki; Fujioka, Masato.
Afiliação
  • Masano Y; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan.
  • Saegusa C; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan.
  • Ishikawa M; Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Division of CNS Regeneration and Drug Discovery, International Center for Brain Science, Fujita Health University, Aichi, Japan.
  • Matsunaga T; Division of Hearing and Balance Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan; Medical Genetics Center, NHO Tokyo Medical Center, Tokyo, Japan.
  • Okano H; Department of Physiology, Keio University School of Medicine, Tokyo, Japan; Division of CNS Regeneration and Drug Discovery, International Center for Brain Science, Fujita Health University, Aichi, Japan; Keio University Regenerative Medicine Research Center, Kanagawa, Japan.
  • Fujioka M; Department of Molecular Genetics, Kitasato University School of Medicine, Kanagawa, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Kanagawa, Japan; Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan; Clinical
Stem Cell Res ; 78: 103452, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38815527
ABSTRACT
We report the establishment of a human induced pluripotent stem cell (iPSC) line from a 54-year-old male patient with an A1555G mutation in the mitochondrial 12S ribosomal RNA gene (MTRNR1), associated with sensorineural hearing loss. The established iPSC line expressed stemness markers or undifferentiated state markers. We also demonstrated the capacity of the cells to differentiate into the three germ layers, suggesting its pluripotency and utility in the pathological study of sensorineural hearing loss and drug screening for ear disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Células-Tronco Pluripotentes Induzidas / Mutação Limite: Humans / Male / Middle aged Idioma: En Revista: Stem Cell Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA Mitocondrial / Células-Tronco Pluripotentes Induzidas / Mutação Limite: Humans / Male / Middle aged Idioma: En Revista: Stem Cell Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão