Renal function affects the safety and efficacy of tirofiban in acute ischemic stroke thrombectomy patients.
Interv Neuroradiol
; : 15910199241256682, 2024 May 31.
Article
em En
| MEDLINE
| ID: mdl-38819373
ABSTRACT
BACKGROUND:
Acute ischemic stroke poses a significant health threat, and thrombectomy has become a routine treatment. Tirofiban has emerged as a promising adjunct therapy to minimize reocclusion after thrombectomy. We aimed to investigate whether renal function influences the safety and efficacy of tirofiban in patients undergoing endovascular therapy.METHODS:
Patients' clinical data collected from the stroke unit were analyzed. The modified Rankin scale score and symptomatic intracranial hemorrhage (sICH) were used as outcome measures.RESULTS:
A total of 409 patients (mean age 66.5 years, 292 males [71.4%]) were included. Tirofiban significantly improved 3-month functional outcomes (adjusted odds ratio [aOR] = 2.408, 95% confidence interval [CI] 1.120-5.175), reduced 3-month mortality (aOR = 0.364, 95% CI 0.155-0.856), and decreased the incidence of sICH (aOR = 0.339, 95% CI 0.149-0.767) in patients with estimated glomerular filtration rate (eGFR) ≥ 90 mL/min/1.73â m². However, no significant improvement in prognosis was observed with tirofiban in patients with eGFR < 90 mL/min/1.73â m². Interaction analysis suggested a potential influence of renal function on tirofiban efficacy.CONCLUSION:
Renal function may impact the efficacy of tirofiban. Administration of tirofiban in direct thrombectomy patients with normal renal function is safe and improves prognosis. However, the prognostic benefits of tirofiban are limited in patients with impaired renal function.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Interv Neuroradiol
Assunto da revista:
NEUROLOGIA
/
RADIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China