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CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer.
Liu, Yanfeng; Wang, Fan; Yan, Guoquan; Tong, Yu; Guo, Wenyun; Li, Songling; Qian, Yifei; Li, Qianyu; Shu, Yu; Zhang, Lei; Zhang, Yonglong; Xia, Qiang.
Afiliação
  • Liu Y; Department of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, China; Shanghai Institute of Transplantation, Shanghai, China. Electronic address: lyf7858188@163.com.
  • Wang F; State Key Laboratory of Systems Medicine for Cancer, Renji-Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Yan G; Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
  • Tong Y; State Key Laboratory of Systems Medicine for Cancer, Renji-Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Guo W; State Key Laboratory of Systems Medicine for Cancer, Renji-Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Li S; School of Biomedical Engineering & Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, China.
  • Qian Y; State Key Laboratory of Systems Medicine for Cancer, Renji-Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Li Q; Department of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Shu Y; State Key Laboratory of Systems Medicine for Cancer, Renji-Med-X Clinical Stem Cell Research Center, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  • Zhang L; Institute of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: threebigrock@163.com.
  • Zhang Y; Central Laboratory, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China. Electronic address: yonglongzhang@126.com.
  • Xia Q; Department of Liver Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Engineering Research Center of Transplantation and Immunology, Shanghai, China; Shanghai Institute of Transplantation, Shanghai, China. Electronic address: xiaqiang@shsmu.edu.cn.
Cancer Lett ; 595: 217006, 2024 Jul 28.
Article em En | MEDLINE | ID: mdl-38823763
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina O-Palmitoiltransferase / Proteína Supressora de Tumor p53 / Carcinoma Hepatocelular / Neoplasias Hepáticas / Mutação Limite: Animals / Humans / Male Idioma: En Revista: Cancer Lett Ano de publicação: 2024 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carnitina O-Palmitoiltransferase / Proteína Supressora de Tumor p53 / Carcinoma Hepatocelular / Neoplasias Hepáticas / Mutação Limite: Animals / Humans / Male Idioma: En Revista: Cancer Lett Ano de publicação: 2024 Tipo de documento: Article