Epidemiologic features and therapeutic strategies of kerion: A nationwide multicentre study.
Mycoses
; 67(6): e13751, 2024 Jun.
Article
em En
| MEDLINE
| ID: mdl-38825584
ABSTRACT
BACKGROUND:
Kerion is a severe type of tinea capitis that is difficult to treat and remains a public health problem.OBJECTIVES:
To evaluate the epidemiologic features and efficacy of different treatment schemes from real-world experience.METHODS:
From 2019 to 2021, 316 patients diagnosed with kerion at 32 tertiary Chinese hospitals were enrolled. We analysed the data of each patient, including clinical characteristics, causative pathogens, treatments and outcomes.RESULTS:
Preschool children were predominantly affected and were more likely to have zoophilic infection. The most common pathogen in China was Microsporum canis. Atopic dermatitis (AD), animal contact, endothrix infection and geophilic pathogens were linked with kerion occurrence. In terms of treatment, itraconazole was the most applied antifungal agent and reduced the time to mycological cure. A total of 22.5% of patients received systemic glucocorticoids simultaneously, which reduced the time to complete symptom relief. Furthermore, glucocorticoids combined with itraconazole had better treatment efficacy, with a higher rate and shorter time to achieving mycological cure.CONCLUSIONS:
Kerion often affects preschoolers and leads to serious sequelae, with AD, animal contact, and endothrix infection as potential risk factors. Glucocorticoids, especially those combined with itraconazole, had better treatment efficacy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tinha do Couro Cabeludo
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Itraconazol
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Microsporum
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Antifúngicos
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Mycoses
/
Mycoses (Berl.)
/
Mycoses (Berlin)
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China