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Kinetics and Durability of Antibody and T-Cell Responses to SARS-CoV-2 in Children.
Files, Megan A; Gentles, Lauren; Kehoe, Leanne; Adler, Amanda; Lacombe, Kirsten; Dickerson, Jane A; Greninger, Alexander; Waghmare, Alpana; Fairlie, Tarayn; Pringle, Kimberly; Midgley, Claire M; Hagen, Melissa Briggs; Englund, Janet A; Seshadri, Chetan.
Afiliação
  • Files MA; Department of Medicine, School of Medicine, University of Washington, Seattle, Washington.
  • Gentles L; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.
  • Kehoe L; Division of Pediatric Infectious Diseases, Seattle Children's Research Institute, Seattle, Washington.
  • Adler A; Division of Pediatric Infectious Diseases, Seattle Children's Research Institute, Seattle, Washington.
  • Lacombe K; Division of Pediatric Infectious Diseases, Seattle Children's Research Institute, Seattle, Washington.
  • Dickerson JA; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, Washington.
  • Greninger A; Department of Laboratories, Seattle Children's Hospital, Seattle, Washington, USA.
  • Waghmare A; Department of Laboratory Medicine and Pathology, School of Medicine, University of Washington, Seattle, Washington.
  • Fairlie T; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
  • Pringle K; Center for Clinical and Translational Research, Seattle Children's Hospital, Seattle, Washington, USA.
  • Midgley CM; Department of Pediatrics, University of Washington, Seattle, Washington.
  • Hagen MB; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Englund JA; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
  • Seshadri C; Coronavirus and Other Respiratory Viruses Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis ; 230(4): 889-900, 2024 Oct 16.
Article em En | MEDLINE | ID: mdl-38838218
ABSTRACT

BACKGROUND:

The kinetics and durability of T-cell responses to SARS-CoV-2 in children are not well characterized. We studied a cohort of children aged 6 months to 20 years with COVID-19 in whom peripheral blood mononuclear cells and sera were archived at approximately 1, 6, and 12 months after symptom onset.

METHODS:

We compared antibody responses (n = 85) and T-cell responses (n = 30) to nucleocapsid (N) and spike (S) glycoprotein over time across 4 age strata 6 months to 5 years and 5-9, 10-14, and 15-20 years.

RESULTS:

N-specific antibody responses declined over time, becoming undetectable in 26 (81%) of 32 children by approximately 1 year postinfection. Functional breadth of anti-N CD4+ T-cell responses also declined over time and were positively correlated with N-antibody responses (Pearson r = .31, P = .008). CD4+ T-cell responses to S displayed greater functional breadth than N in unvaccinated children and, with neutralization titers, were stable over time and similar across age strata. Functional profiles of CD4+ T-cell responses against S were not significantly modulated by vaccination.

CONCLUSIONS:

Our data reveal durable age-independent T-cell immunity to SARS-CoV-2 structural proteins in children over time following COVID-19 infection as well as S-antibody responses in comparison with declining antibody responses to N.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Glicoproteína da Espícula de Coronavírus / SARS-CoV-2 / COVID-19 / Anticorpos Antivirais Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article