Your browser doesn't support javascript.
loading
Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans.
Aleksic, Sandra; Fleysher, Roman; Weiss, Erica F; Tal, Noa; Darby, Timothy; Blumen, Helena M; Vazquez, Juan; Ye, Kenny Q; Gao, Tina; Siegel, Shira M; Barzilai, Nir; Lipton, Michael L; Milman, Sofiya.
Afiliação
  • Aleksic S; Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, United States. Electronic address: sandra.aleksic@einsteinmed.edu.
  • Fleysher R; Department of Radiology, Columbia University Irving Medical Center, New York, NY, United States; Department of Radiology, Albert Einstein College of Medicine, Gruss Magnetic Resonance Research Center, Bronx, NY, United States.
  • Weiss EF; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States.
  • Tal N; Department of Medicine, Cedars-Sinai, Los Angeles, CA, United States.
  • Darby T; Albert Einstein College of Medicine, Bronx, NY, United States.
  • Blumen HM; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, United States.
  • Vazquez J; Department of Internal Medicine, John Hopkins University, Baltimore, MD, United States.
  • Ye KQ; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY, United States.
  • Gao T; Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, United States.
  • Siegel SM; Department of Radiology, Columbia University Irving Medical Center, New York, NY, United States.
  • Barzilai N; Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, United States.
  • Lipton ML; Department of Radiology, Columbia University Irving Medical Center, New York, NY, United States; Department of Biomedical Engineering, Columbia University, New York, NY, United States.
  • Milman S; Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY, United States; Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, United States.
Neurobiol Aging ; 141: 102-112, 2024 Sep.
Article em En | MEDLINE | ID: mdl-38850591
ABSTRACT
The hypothalamus regulates homeostasis across the lifespan and is emerging as a regulator of aging. In murine models, aging-related changes in the hypothalamus, including microinflammation and gliosis, promote accelerated neurocognitive decline. We investigated relationships between hypothalamic microstructure and features of neurocognitive aging, including cortical thickness and cognition, in a cohort of community-dwelling older adults (age range 65-97 years, n=124). Hypothalamic microstructure was evaluated with two magnetic resonance imaging diffusion metrics mean diffusivity (MD) and fractional anisotropy (FA), using a novel image processing pipeline. Hypothalamic MD was cross-sectionally positively associated with age and it was negatively associated with cortical thickness. Hypothalamic FA, independent of cortical thickness, was cross-sectionally positively associated with neurocognitive scores. An exploratory analysis of longitudinal neurocognitive performance suggested that lower hypothalamic FA may predict cognitive decline. No associations between hypothalamic MD, age, and cortical thickness were identified in a younger control cohort (age range 18-63 years, n=99). To our knowledge, this is the first study to demonstrate that hypothalamic microstructure is associated with features of neurocognitive aging in humans.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Cognição / Envelhecimento Cognitivo / Hipotálamo Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurobiol Aging Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Envelhecimento / Cognição / Envelhecimento Cognitivo / Hipotálamo Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Neurobiol Aging Ano de publicação: 2024 Tipo de documento: Article