Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression.

Jang, Hyun-Ji; Min, Hye-Young; Kang, Yun Pyo; Boo, Hye-Jin; Kim, Jisung; Ahn, Jee Hwan; Oh, Seung Ho; Jung, Jin Hwa; Park, Choon-Sik; Park, Jong-Sook; Kim, Seog-Young; Lee, Ho-Young

Jang, Hyun-Ji; Min, Hye-Young; Kang, Yun Pyo; Boo, Hye-Jin; Kim, Jisung; Ahn, Jee Hwan; Oh, Seung Ho; Jung, Jin Hwa; Park, Choon-Sik; Park, Jong-Sook; Kim, Seog-Young; Lee, Ho-Young.

Afiliação

Jang HJ; Creative Research Initiative Center for concurrent control of emphysema and lung cancer, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Min HY; Creative Research Initiative Center for concurrent control of emphysema and lung cancer, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Kang YP; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Boo HJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Kim J; Creative Research Initiative Center for concurrent control of emphysema and lung cancer, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Ahn JH; Department of Histology, College of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Oh SH; Creative Research Initiative Center for concurrent control of emphysema and lung cancer, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Jung JH; Creative Research Initiative Center for concurrent control of emphysema and lung cancer, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Park CS; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Pharmacy, Seoul National University, Seoul, 08826, Republic of Korea.
Park JS; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Kim SY; PET core, Convergence Medicine Research Center, Asan Medical Center, Seoul, 05505, Republic of Korea.
Lee HY; Soonchunhyang University Bucheon Hospital, Bucheon-si, Gyeonggi-do, 14584, Republic of Korea.

Nat Commun ; 15(1): 4909, 2024 Jun 08.

Article em En | MEDLINE | ID: mdl-38851766

Assuntos

Antígeno B7-H1; Benzo(a)pireno; Progressão da Doença; Hiperglicemia; Fator de Crescimento Insulin-Like II; Neoplasias Pulmonares; Camundongos Endogâmicos C57BL; Proteínas Nucleares; Nucleofosmina; Receptor de Insulina; Animais; Neoplasias Pulmonares/metabolismo; Neoplasias Pulmonares/patologia; Neoplasias Pulmonares/genética; Masculino; Humanos; Receptor de Insulina/metabolismo; Receptor de Insulina/genética; Camundongos; Antígeno B7-H1/metabolismo; Antígeno B7-H1/genética; Hiperglicemia/metabolismo; Benzo(a)pireno/toxicidade; Fator de Crescimento Insulin-Like II/metabolismo; Fator de Crescimento Insulin-Like II/genética; Proteínas Nucleares/metabolismo; Proteínas Nucleares/genética; Nitrosaminas/toxicidade; Macrófagos Associados a Tumor/metabolismo; Linhagem Celular Tumoral; Comunicação Parácrina; Regulação Neoplásica da Expressão Gênica; Fumar/efeitos adversos; Macrófagos/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzo(a)pireno / Fator de Crescimento Insulin-Like II / Receptor de Insulina / Proteínas Nucleares / Progressão da Doença / Antígeno B7-H1 / Nucleofosmina / Hiperglicemia / Neoplasias Pulmonares / Camundongos Endogâmicos C57BL Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2024 Tipo de documento: Article

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