Cortical nitric oxide required for presynaptic long-term potentiation in the insular cortex.
Philos Trans R Soc Lond B Biol Sci
; 379(1906): 20230475, 2024 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-38853563
ABSTRACT
Nitric oxide (NO) is a key diffusible messenger in the mammalian brain. It has been proposed that NO may diffuse retrogradely into presynaptic terminals, contributing to the induction of hippocampal long-term potentiation (LTP). Here, we present novel evidence that NO is required for kainate receptor (KAR)-dependent presynaptic form of LTP (pre-LTP) in the adult insular cortex (IC). In the IC, we found that inhibition of NO synthase erased the maintenance of pre-LTP, while the induction of pre-LTP required the activation of KAR. Furthermore, NO is essential for pre-LTP induced between two pyramidal cells in the IC using the double patch-clamp recording. These results suggest that NO is required for homosynaptic pre-LTP in the IC. Our results present strong evidence for the critical roles of NO in pre-LTP in the IC. This article is part of a discussion meeting issue 'Long-term potentiation 50 years on'.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Terminações Pré-Sinápticas
/
Potenciação de Longa Duração
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Philos Trans R Soc Lond B Biol Sci
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão