Real-world study: Impact of multidisciplinary management of apalutamide-associated adverse events in prostate cancer.
Prostate
; 84(13): 1198-1208, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38888199
ABSTRACT
OBJECTIVE:
To analyse the adverse events (AEs) associated with apalutamide and the impact of a multidisciplinary team (MDT) protocol on its management at a tertiary care hospital in a real-world setting.METHODS:
This was an observational, prospective, cohort study based on real-world evidence at the Hospital Clínic de Barcelona. Includes patients diagnosed with metastatic hormone-sensitive prostate cancer (mHSPC) or high-risk nonmetastatic castration-resistant prostate cancer (nmCRPC) and who started treatment with apalutamide between May 2019 and March 2023 in a real-world clinical setting.RESULTS:
Of the 121 patients treated with apalutamide, 52.1% experienced an AE, 19.8% experienced temporarily interruption or a reduction in the dose of apalutamide, and 13.2% discontinued treatment due to AEs. Without MDT protocol (49 patients), 24.5% of patients had to temporarily interrupt or reduce the dose of apalutamide due to AEs, with a median time from the start of treatment of 10.1 months, and 24.5% discontinued apalutamide due to AEs, with a median time from the start of treatment of 3.1 months. Meanwhile, whit MDT protocol (72 patients), 16.7% of patients had to temporarily interrupt or reduce the dose of apalutamide due to AEs, with a median time from the start of treatment of 1.6 months, and 5.6% discontinued apalutamide due to AEs, with a median time from the start of treatment of 4 months. The risk reduction associated with treatment discontinuation was statistically significant (p-value = 0.003).CONCLUSIONS:
This study highlights the importance of MDT management of AEs associated with apalutamide to reduce treatment discontinuation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Tioidantoínas
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Neoplasias de Próstata Resistentes à Castração
Limite:
Aged
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Aged80
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Prostate
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Espanha