Biochemical liver damage during gender affirming therapy in trans adults assigned female at birth: a meta-analysis.
J Endocrinol Invest
; 2024 Jun 22.
Article
em En
| MEDLINE
| ID: mdl-38909133
ABSTRACT
PURPOSE:
To assess the effects of testosterone (T)-based gender affirming hormone therapy (GAHT) on liver blood tests (LBTs) in assigned female at birth adults, using a meta-analytic approach.METHODS:
Prospective and retrospective studies were selected that reported the prevalence of biochemical liver damage (BLD) and LBTs changes during T therapy. Data collected included pre-and-during therapy alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), gamma-glutamyl-transferase (GGT), and alkaline phosphatase (ALP) mean concentration values.RESULTS:
The prevalence of BLD in 14 studies on 1698 subjects was 1% (95% CI 0.00-3.00; I2 = 14.1%; p = 0.82). In 17 studies on 2758 subjects, GAHT was associated with a statistically (but not clinically) significant increase in AST, GGT and ALP at 12 months and ALT at 3-7 (MD 1.19 IU/l; 95% CI 0.31, 2.08; I2 0%), at 12 (MD 2.31 IU/l; 95% CI 1.41, 3.21; I2 29%), but with no more significant increase at 24 months (MD 1.71 IU/l; 95% CI -0.02, 3.44; I2 0%).CONCLUSIONS:
Analysis of aggregate estimates confirms a low risk of BLD and abnormalities in LBTs, transient in most cases, during T-based GAHT, thus suggesting a limited need for careful liver monitoring in AFAB people.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália