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Phosphine-Catalyzed Ring-Opening Regioselective Addition of Cyclopropenones with Amides.
Wang, Huamin; Wei, Yibo; He, Yongjun; He, Tian-Juan; Lin, Ying-Wu.
Afiliação
  • Wang H; School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China.
  • Wei Y; School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China.
  • He Y; School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China.
  • He TJ; School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China.
  • Lin YW; School of Chemistry and Chemical Engineering, University of South China, Hengyang 421001, P. R. China.
J Org Chem ; 89(14): 10093-10098, 2024 Jul 19.
Article em En | MEDLINE | ID: mdl-38935753
ABSTRACT
A series of amides, including α-bromo hydroxamates, N-alkoxyamides, and N-aryloxyamides, were subjected to phosphine-catalyzed ring-opening O-selective addition with cyclopropenones, producing various special α,ß-unsaturated esters containing oxime ether motif, in moderate to excellent yields, with high regioselectivity, and exclusive O-selectivity. The methodology is highly atom-economical, with simple operation procedures, and compatible with a wide substrate scope (more than 44 examples).

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Org Chem Ano de publicação: 2024 Tipo de documento: Article