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Evolutionary and biomedical implications of sex differences in the primate brain transcriptome.
DeCasien, Alex R; Chiou, Kenneth L; Testard, Camille; Mercer, Arianne; Negrón-Del Valle, Josué E; Bauman Surratt, Samuel E; González, Olga; Stock, Michala K; Ruiz-Lambides, Angelina V; Martínez, Melween I; Antón, Susan C; Walker, Christopher S; Sallet, Jérôme; Wilson, Melissa A; Brent, Lauren J N; Montague, Michael J; Sherwood, Chet C; Platt, Michael L; Higham, James P; Snyder-Mackler, Noah.
Afiliação
  • DeCasien AR; Department of Anthropology, New York University, New York, NY, USA; New York Consortium in Evolutionary Primatology, New York, NY, USA; Section on Developmental Neurogenomics, National Institute of Mental Health, Bethesda, MD, USA. Electronic address: alex.decasien@gmail.com.
  • Chiou KL; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; Department of Psychology, University of Washington, Seattle, WA, USA; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washing
  • Testard C; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
  • Mercer A; Department of Psychology, University of Washington, Seattle, WA, USA.
  • Negrón-Del Valle JE; School of Life Sciences, Arizona State University, Tempe, AZ, USA.
  • Bauman Surratt SE; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • González O; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
  • Stock MK; Department of Sociology and Anthropology, Metropolitan State University of Denver, Denver, CO, USA.
  • Ruiz-Lambides AV; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • Martínez MI; Caribbean Primate Research Center, University of Puerto Rico, San Juan, PR, USA.
  • Antón SC; Department of Anthropology, New York University, New York, NY, USA; New York Consortium in Evolutionary Primatology, New York, NY, USA.
  • Walker CS; Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
  • Sallet J; Stem Cell and Brain Research Institute, Université Lyon, Lyon, France.
  • Wilson MA; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; Biodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, AZ, USA.
  • Brent LJN; Centre for Research in Animal Behavior, University of Exeter, Exeter, UK.
  • Montague MJ; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA.
  • Sherwood CC; Department of Anthropology, The George Washington University, Washington, DC, USA.
  • Platt ML; Department of Neuroscience, University of Pennsylvania, Philadelphia, PA, USA; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA; Department of Marketing, University of Pennsylvania, Philadelphia, PA, USA.
  • Higham JP; Department of Anthropology, New York University, New York, NY, USA; New York Consortium in Evolutionary Primatology, New York, NY, USA. Electronic address: jhigham@nyu.edu.
  • Snyder-Mackler N; Center for Evolution and Medicine, Arizona State University, Tempe, AZ, USA; School of Life Sciences, Arizona State University, Tempe, AZ, USA; Department of Psychology, University of Washington, Seattle, WA, USA; Nathan Shock Center of Excellence in the Basic Biology of Aging, University of Washing
Cell Genom ; 4(7): 100589, 2024 Jul 10.
Article em En | MEDLINE | ID: mdl-38942023
ABSTRACT
Humans exhibit sex differences in the prevalence of many neurodevelopmental disorders and neurodegenerative diseases. Here, we generated one of the largest multi-brain-region bulk transcriptional datasets for the rhesus macaque and characterized sex-biased gene expression patterns to investigate the translatability of this species for sex-biased neurological conditions. We identify patterns similar to those in humans, which are associated with overlapping regulatory mechanisms, biological processes, and genes implicated in sex-biased human disorders, including autism. We also show that sex-biased genes exhibit greater genetic variance for expression and more tissue-specific expression patterns, which may facilitate rapid evolution of sex-biased genes. Our findings provide insights into the biological mechanisms underlying sex-biased disease and support the rhesus macaque model for the translational study of these conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Caracteres Sexuais / Transcriptoma / Macaca mulatta Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Genom Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Caracteres Sexuais / Transcriptoma / Macaca mulatta Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Genom Ano de publicação: 2024 Tipo de documento: Article