<i>Lycium barbarum</i> polysaccharides regulate the gut microbiota to modulate metabolites in high-fat diet-induced obese rats.

Fan, Yan-Na; Chi, Xi; Yan, Lu; Pu, Zhi-Yu; Yang, Jian-Jun; Zhang, Yan-Nan

Lycium barbarum polysaccharides regulate the gut microbiota to modulate metabolites in high-fat diet-induced obese rats.

Fan, Yan-Na; Chi, Xi; Yan, Lu; Pu, Zhi-Yu; Yang, Jian-Jun; Zhang, Yan-Nan.

Afiliação

Fan YN; Department of Nutrition and Food Hygiene, School of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Chi X; Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan 750004, China.
Yan L; Department of Nutrition and Food Hygiene, School of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Pu ZY; Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan 750004, China.
Yang JJ; Department of Nutrition and Food Hygiene, School of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Zhang YN; Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia Medical University, Yinchuan 750004, China.

J Asian Nat Prod Res ; 26(9): 1115-1129, 2024 Sep.

Article em En | MEDLINE | ID: mdl-38952165

ABSTRACT

ABSTRACT

Lycium Barbarum Polysaccharides (LBP) can benefit lipid parameters such as total cholesterol, triglyceride, and high-density lipoprotein levels and upregulate the level of Firmicutes, increase the diversity of gut microbiota and reduce metabolic disorders, finally relieving weight gain of obese rats. But it cannot reverse the outcome of obesity. Over 30 differential metabolites and four pathways are altered by LBP.

Assuntos

Dieta Hiperlipídica; Medicamentos de Ervas Chinesas; Microbioma Gastrointestinal; Obesidade; Animais; Microbioma Gastrointestinal/efeitos dos fármacos; Obesidade/tratamento farmacológico; Ratos; Medicamentos de Ervas Chinesas/farmacologia; Medicamentos de Ervas Chinesas/química; Masculino; Lycium/química; Estrutura Molecular; Triglicerídeos/sangue; Triglicerídeos/metabolismo; Ratos Sprague-Dawley; Polissacarídeos/farmacologia; Polissacarídeos/química

Palavras-chave

Lycium barbarum polysaccharides; Obesity; gut microbiome; metabolite

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Dieta Hiperlipídica / Microbioma Gastrointestinal / Obesidade Limite: Animals Idioma: En Revista: J Asian Nat Prod Res Assunto da revista: BOTANICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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