Scutellarin alleviates renal ischemia-reperfusion injury by inhibiting the MAPK pathway and pro-inflammatory macrophage polarization.

Deng, Ge; Zheng, Bingxuan; Dou, Meng; Gao, Yang; Zhang, Xingzhe; Niu, Zejiaxin; Wei, Tian; Han, Feng; Ding, Chenguang; Tian, Puxun

Deng, Ge; Zheng, Bingxuan; Dou, Meng; Gao, Yang; Zhang, Xingzhe; Niu, Zejiaxin; Wei, Tian; Han, Feng; Ding, Chenguang; Tian, Puxun.

Afiliação

Deng G; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zheng B; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Dou M; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Gao Y; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Zhang X; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Niu Z; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Wei T; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Han F; Department of Burn and Plastic Surgery, Shaanxi Provincial People's Hospital, Xi'an, China.
Ding C; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Tian P; Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

FASEB J ; 38(13): e23769, 2024 Jul 15.

Article em En | MEDLINE | ID: mdl-38958951

Assuntos

Apigenina; Glucuronatos; Sistema de Sinalização das MAP Quinases; Macrófagos; Traumatismo por Reperfusão; Animais; Masculino; Camundongos; Apigenina/farmacologia; Apoptose/efeitos dos fármacos; Glucuronatos/farmacologia; Glucuronatos/uso terapêutico; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Inflamação/prevenção & controle; Inflamação/patologia; Rim/metabolismo; Rim/efeitos dos fármacos; Rim/patologia; Macrófagos/efeitos dos fármacos; Macrófagos/metabolismo; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Camundongos Endogâmicos C57BL; Células RAW 264.7; Traumatismo por Reperfusão/tratamento farmacológico; Traumatismo por Reperfusão/metabolismo

Palavras-chave

macrophage; macrophage polarization; renal ischemiareperfusion injury; scutellarin; the MAPK pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Sistema de Sinalização das MAP Quinases / Apigenina / Glucuronatos / Macrófagos Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

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