Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model.
Science
; 385(6704): 80-86, 2024 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-38963846
ABSTRACT
Classical migraine patients experience aura, which is transient neurological deficits associated with cortical spreading depression (CSD), preceding headache attacks. It is not currently understood how a pathological event in cortex can affect peripheral sensory neurons. In this study, we show that cerebrospinal fluid (CSF) flows into the trigeminal ganglion, establishing nonsynaptic signaling between brain and trigeminal cells. After CSD, ~11% of the CSF proteome is altered, with up-regulation of proteins that directly activate receptors in the trigeminal ganglion. CSF collected from animals exposed to CSD activates trigeminal neurons in naïve mice in part by CSF-borne calcitonin gene-related peptide (CGRP). We identify a communication pathway between the central and peripheral nervous system that might explain the relationship between migrainous aura and headache.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depressão Alastrante da Atividade Elétrica Cortical
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Peptídeo Relacionado com Gene de Calcitonina
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Gânglio Trigeminal
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Transtornos de Enxaqueca
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Dinamarca