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Triptonide induces apoptosis and inhibits the proliferation of ovarian cancer cells by activating the p38/p53 pathway and autophagy.
Lou, Ruoxuan; Yang, Taohua; Zhang, Xiaoying; Gu, Jianyi; Xue, LuJiadai; Gan, Danhui; Li, Haijing; Li, Qiang; Chen, Yuanhong; Jiang, Jianwei.
Afiliação
  • Lou R; Department of Biochemistry, Basic Medical College of Jinan University, Guangzhou 510632, China.
  • Yang T; Department of Hepatobiliary Surgery, Yangchun People's Hospital, Yangchu 529600, Guangdong Province, China.
  • Zhang X; Department of Pathology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou 511486, China.
  • Gu J; Department of Biochemistry, Basic Medical College of Jinan University, Guangzhou 510632, China.
  • Xue L; Department of Gynaecology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Gan D; Department of Pathology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Li H; Department of Gynecology, The Sixth Affiliated Hospital of Jinan University, Dongguan Eastern Central Hospital, Dongguan 523560, China.
  • Li Q; Department of Hepatobiliary Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China.
  • Chen Y; Department of Gynecology, The Sixth Affiliated Hospital of Jinan University, Dongguan Eastern Central Hospital, Dongguan 523560, China. Electronic address: 13712224028@163.com.
  • Jiang J; Department of Biochemistry, Basic Medical College of Jinan University, Guangzhou 510632, China. Electronic address: jjw703@jnu.edu.cn.
Bioorg Med Chem ; 110: 117788, 2024 Aug 01.
Article em En | MEDLINE | ID: mdl-38964974
ABSTRACT
Ovarian cancer is a common malignant tumor in women, and 70 % of ovarian cancer patients are diagnosed at an advanced stage. Drug chemotherapy is an important method for treating ovarian cancer, but recurrence and chemotherapy resistance often lead to treatment failure. In this study, we screened 10 extracts of Tripterygium wilfordii, a traditional Chinese herb, and found that triptonide had potent anti-ovarian cancer activity and an IC50 of only 3.803 nM against A2780 cell lines. In addition, we determined that triptonide had a better antitumor effect on A2780 cell lines than platinum chemotherapeutic agents in vitro and that triptonide had no significant side effects in vivo. We found that triptonide induced apoptosis in ovarian cancer cells through activation of the p38/p53 pathway and it also induced cell cycle arrest at the S phase. In addition, we demonstrated that triptonide could activate lethal autophagy, which led to growth inhibition and cell death in ovarian cancer cells, resulting in an anti-ovarian cancer effect. Triptonide exerts its anti-ovarian cancer effect through activation of the p38/p53 pathway and induction of autophagy to promote apoptosis, which provides a new candidate drug and strategy for the treatment of ovarian cancer.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Autofagia / Triterpenos / Proteína Supressora de Tumor p53 / Apoptose / Proteínas Quinases p38 Ativadas por Mitógeno / Proliferação de Células Limite: Female / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Autofagia / Triterpenos / Proteína Supressora de Tumor p53 / Apoptose / Proteínas Quinases p38 Ativadas por Mitógeno / Proliferação de Células Limite: Female / Humans Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China