Tear Fluid as a Matrix for Biomonitoring Environmental and Chemical Exposures.
Curr Environ Health Rep
; 11(3): 340-355, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38967858
ABSTRACT
PURPOSE:
Exposures to hazardous chemicals have been linked to many detrimental health effects and it is therefore critical to have effective biomonitoring methods to better evaluate key environmental exposures that increase the risk of chronic disease and death. Traditional biomonitoring utilizing blood and urine is limited due to the specialized skills and invasiveness of collecting these fluid samples. This systematic review focuses on tear fluid, which is largely under-researched, as a promising complementary matrix to the traditional fluids used for biomonitoring. The objective is to evaluate the practicability of using human tear fluid for biomonitoring environmental exposures, highlighting potential pitfalls and opportunities. RECENTFINDING:
Tear fluid biomonitoring represents a promising method for assessing exposures because it can be collected with minimal invasiveness and tears contain exposure markers from both the external and internal environments. Tear fluid uniquely interfaces with the external environment at the air-tear interface, providing a surface for airborne chemicals to diffuse into the ocular environment and interact with biomolecules. Tear fluid also contains molecules from the internal environment that have travelled from the blood to tears by crossing the blood-tear barrier. This review demonstrates that tear fluid can be used to identify hazardous chemicals from the external environment and differentiate exposure groups.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lágrimas
/
Exposição Ambiental
/
Monitoramento Biológico
Limite:
Humans
Idioma:
En
Revista:
Curr Environ Health Rep
/
Curr. Environ. Health Rep
/
Current environmental health reports
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Canadá