Multi-day neuron tracking in high-density electrophysiology recordings using earth mover's distance.
Elife
; 122024 Jul 10.
Article
em En
| MEDLINE
| ID: mdl-38985568
ABSTRACT
Accurate tracking of the same neurons across multiple days is crucial for studying changes in neuronal activity during learning and adaptation. Advances in high-density extracellular electrophysiology recording probes, such as Neuropixels, provide a promising avenue to accomplish this goal. Identifying the same neurons in multiple recordings is, however, complicated by non-rigid movement of the tissue relative to the recording sites (drift) and loss of signal from some neurons. Here, we propose a neuron tracking method that can identify the same cells independent of firing statistics, that are used by most existing methods. Our method is based on between-day non-rigid alignment of spike-sorted clusters. We verified the same cell identity in mice using measured visual receptive fields. This method succeeds on datasets separated from 1 to 47 days, with an 84% average recovery rate.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Elife
/
ELife (Cambridge)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos