Your browser doesn't support javascript.
loading
Consistently lower volumes across thalamus nuclei in very premature-born adults.
Thalhammer, Melissa; Nimpal, Mehul; Schulz, Julia; Meedt, Veronica; Menegaux, Aurore; Schmitz-Koep, Benita; Daamen, Marcel; Boecker, Henning; Zimmer, Claus; Priller, Josef; Wolke, Dieter; Bartmann, Peter; Hedderich, Dennis; Sorg, Christian.
Afiliação
  • Thalhammer M; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany. Electronic address: melissa.thalhammer@tum.de.
  • Nimpal M; Faculty of Biology, Graduate School of Systemic Neurosciences, Ludwig Maximilian University of Munich.
  • Schulz J; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany.
  • Meedt V; Faculty of Biology, Ludwig Maximilian University of Munich.
  • Menegaux A; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany.
  • Schmitz-Koep B; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany.
  • Daamen M; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Clinical Functional Imaging Group, Bonn, Germany; Department of Neonatology and Pediatric Intensive Care, University Hospital Bonn, Bonn, Germany.
  • Boecker H; Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Clinical Functional Imaging Group, Bonn, Germany.
  • Zimmer C; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany.
  • Priller J; Department of Psychiatry, Technical University of Munich, School of Medicine and Health, Munich, Germany.
  • Wolke D; Department of Psychology, University of Warwick, Coventry, UK; Warwick Medical School, University of Warwick, Coventry, UK.
  • Bartmann P; Department of Neonatology and Pediatric Intensive Care, University Hospital Bonn, Bonn, Germany.
  • Hedderich D; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany.
  • Sorg C; Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, School of Medicine and Health, Munich, Germany; Technical University of Munich, School of Medicine and Health, TUM-NIC Neuroimaging Center, Munich, Germany; Department of Psychiatry, Technical University of M
Neuroimage ; 297: 120732, 2024 Aug 15.
Article em En | MEDLINE | ID: mdl-39004408
ABSTRACT
Lasting thalamus volume reduction after preterm birth is a prominent finding. However, whether thalamic nuclei volumes are affected differentially by preterm birth and whether nuclei aberrations are relevant for cognitive functioning remains unknown. Using T1-weighted MR-images of 83 adults born very preterm (≤ 32 weeks' gestation; VP) and/or with very low body weight (≤ 1,500 g; VLBW) as well as of 92 full-term born (≥ 37 weeks' gestation) controls, we compared thalamic nuclei volumes of six subregions (anterior, lateral, ventral, intralaminar, medial, and pulvinar) across groups at the age of 26 years. To characterize the functional relevance of volume aberrations, cognitive performance was assessed by full-scale intelligence quotient using the Wechsler Adult Intelligence Scale and linked to volume reductions using multiple linear regression analyses. Thalamic volumes were significantly lower across all examined nuclei in VP/VLBW adults compared to controls, suggesting an overall rather than focal impairment. Lower nuclei volumes were linked to higher intensity of neonatal treatment, indicating vulnerability to stress exposure after birth. Furthermore, we found that single results for lateral, medial, and pulvinar nuclei volumes were associated with full-scale intelligence quotient in preterm adults, albeit not surviving correction for multiple hypotheses testing. These findings provide evidence that lower thalamic volume in preterm adults is observable across all subregions rather than focused on single nuclei. Data suggest the same mechanisms of aberrant thalamus development across all nuclei after premature birth.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleos Talâmicos / Imageamento por Ressonância Magnética Limite: Adult / Female / Humans / Male / Newborn Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Núcleos Talâmicos / Imageamento por Ressonância Magnética Limite: Adult / Female / Humans / Male / Newborn Idioma: En Revista: Neuroimage Assunto da revista: DIAGNOSTICO POR IMAGEM Ano de publicação: 2024 Tipo de documento: Article