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On the use of the healthy lifestyle index to investigate specific disease outcomes.
Viallon, Vivian; Freisling, Heinz; Matta, Komodo; Nannsen, Anne Østergaard; Dahm, Christina C; Tjønneland, Anne; Eriksen, Anne Kirstine; Kaaks, Rudolf; Katzke, Verena A; Schulze, Matthias B; Masala, Giovanna; Tagliabue, Giovanna; Simeon, Vittorio; Tumino, Rosario; Milani, Lorenzo; Derksen, Jeroen W G; van der Schouw, Yvonne T; Nøst, Therese Haugdahl; Borch, Kristin Benjaminsen; Sandanger, Torkjel M; Quirós, J Ramón; Rodriguez-Barranco, Miguel; Bonet, Catalina; Aizpurua-Atxega, Amaia; Cirera, Lluís; Guevara, Marcela; Sundström, Björn; Winkvist, Anna; Heath, Alicia K; Gunter, Marc J; Weiderpass, Elisabete; Johansson, Mattias; Ferrari, Pietro.
Afiliação
  • Viallon V; International Agency for Research On Cancer (IARC-WHO), Lyon, France. viallonv@iarc.who.int.
  • Freisling H; International Agency for Research On Cancer (IARC-WHO), Lyon, France.
  • Matta K; International Agency for Research On Cancer (IARC-WHO), Lyon, France.
  • Nannsen AØ; Department of Public Health, Aarhus University, Aarhus, Denmark.
  • Dahm CC; Department of Public Health, Aarhus University, Aarhus, Denmark.
  • Tjønneland A; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Eriksen AK; Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  • Kaaks R; Danish Cancer Society Research Center, Copenhagen, Denmark.
  • Katzke VA; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Schulze MB; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  • Masala G; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  • Tagliabue G; German Center for Diabetes Research (DZD), Neuherberg, Germany.
  • Simeon V; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany.
  • Tumino R; Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy.
  • Milani L; Cancer Registry Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy.
  • Derksen JWG; Unit of Medical Statistics, University "L. Vanvitelli", Naples, Italy.
  • van der Schouw YT; Hyblean Association for Epidemiological Research, AIRE-ONLUS, Ragusa, Italy.
  • Nøst TH; Unit of Cancer Epidemiology, Città Della Salute E Della Scienza University-Hospital, and Center for Cancer Prevention (CPO), Turin, Italy.
  • Borch KB; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Sandanger TM; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Quirós JR; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU - Norwegian University of Science and Technology, Trondheim, Norway.
  • Rodriguez-Barranco M; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Bonet C; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Aizpurua-Atxega A; Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway.
  • Cirera L; Public Health Directorate, Asturias, Spain.
  • Guevara M; Escuela Andaluza de Salud Pública (EASP), Granada, Spain.
  • Sundström B; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain.
  • Winkvist A; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
  • Heath AK; Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Gunter MJ; Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
  • Weiderpass E; Sub Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, San Sebastián, Spain.
  • Johansson M; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain.
  • Ferrari P; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Sci Rep ; 14(1): 16330, 2024 07 15.
Article em En | MEDLINE | ID: mdl-39009699
ABSTRACT
The healthy lifestyle index (HLI), defined as the unweighted sum of individual lifestyle components, was used to investigate the combined role of lifestyle factors on health-related outcomes. We introduced weighted outcome-specific versions of the HLI, where individual lifestyle components were weighted according to their associations with disease outcomes. Within the European Prospective Investigation into Cancer and Nutrition (EPIC), we examined the association between the standard and the outcome-specific HLIs and the risk of T2D, CVD, cancer, and all-cause premature mortality. Estimates of the hazard ratios (HRs), the Harrell's C-index and the population attributable fractions (PAFs) were compared. For T2D, the HR for 1-SD increase of the standard and T2D-specific HLI were 0.66 (95% CI 0.64, 0.67) and 0.43 (0.42, 0.44), respectively, and the C-index were 0.63 (0.62, 0.64) and 0.72 (0.72, 0.73). Similar, yet less pronounced differences in HR and C-index were observed for standard and outcome-specific estimates for cancer, CVD and all-cause mortality. PAF estimates for mortality before age 80 were 57% (55%, 58%) and 33% (32%, 34%) for standard and mortality-specific HLI, respectively. The use of outcome-specific HLI could improve the assessment of the role of lifestyle factors on disease outcomes, thus enhancing the definition of public health recommendations.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Estilo de Vida Saudável / Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Estilo de Vida Saudável / Neoplasias Limite: Adult / Aged / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Revista: Sci Rep Ano de publicação: 2024 Tipo de documento: Article País de afiliação: França