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Pneumococcal carriage and disease in adults in England 2011-2019: the importance of adults as a reservoir for pneumococcus in communities.
El Safadi, D; Hitchins, L; Howard, A; Aley, P; Bowman, J; Bertran, M; Collins, A; Colin-Jones, R; Elterish, F; Fry, N K; Gordon, S B; Gould, K; Hinds, J; Horn, E; Hyder-Wright, A; Kandasamy, R; Ladhani, S; Litt, D; Mitsi, E; Murphy, A; Pollard, A J; Plested, E; Pojar, S; Ratcliffe, H; Robertson, M C; Robinson, H; Snape, M D; Solórzano, C; Voysey, M; Begier, E; Catusse, J; Lahuerta, M; Theilacker, C; Gessner, B D; Tiley, K S; Ferreira, D M.
Afiliação
  • El Safadi D; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Hitchins L; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Howard A; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Aley P; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Bowman J; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford, United Kingdom.
  • Bertran M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Collins A; Immunisations and Vaccine Preventable Diseases, UK Health Security Agency (UKHSA), London, United Kingdom.
  • Colin-Jones R; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Elterish F; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Fry NK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Gordon SB; Immunisations and Vaccine Preventable Diseases, UK Health Security Agency (UKHSA), London, United Kingdom.
  • Gould K; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Hinds J; Institute for Infection and Immunity, St George's University, London, United Kingdom.
  • Horn E; BUGS Bioscience, London Bioscience Innovation Centre, London, United Kingdom.
  • Hyder-Wright A; Institute for Infection and Immunity, St George's University, London, United Kingdom.
  • Kandasamy R; BUGS Bioscience, London Bioscience Innovation Centre, London, United Kingdom.
  • Ladhani S; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Litt D; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Mitsi E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Murphy A; Immunisations and Vaccine Preventable Diseases, UK Health Security Agency (UKHSA), London, United Kingdom.
  • Pollard AJ; Immunisations and Vaccine Preventable Diseases, UK Health Security Agency (UKHSA), London, United Kingdom.
  • Plested E; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Pojar S; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Ratcliffe H; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Robertson MC; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Robinson H; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Snape MD; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford, United Kingdom.
  • Solórzano C; National Institute for Health Research Clinical Research Network, Thames Valley and South Midlands, Oxford, United Kingdom.
  • Voysey M; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Begier E; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Catusse J; Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  • Lahuerta M; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Theilacker C; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford, United Kingdom.
  • Gessner BD; National Institute for Health Research Clinical Research Network, Thames Valley and South Midlands, Oxford, United Kingdom.
  • Tiley KS; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom.
  • Ferreira DM; National Institute for Health Research, Oxford Biomedical Research Centre, Oxford, United Kingdom.
J Infect Dis ; 2024 Jul 16.
Article em En | MEDLINE | ID: mdl-39013016
ABSTRACT

BACKGROUND:

Pneumococcal carriage in children has been extensively studied, but carriage in healthy adults and its relationship to invasive pneumococcal disease (IPD) is less understood.

METHODS:

Nasal wash samples from adults without close contact with young children (Liverpool, UK), 2011-2019, were cultured, and culture-negative samples tested by PCR. Pneumococcal carriage in adults 18-44 years was compared with carriage among PCV-vaccinated children 13-48 months (nasopharyngeal swabs, Thames Valley, UK) and IPD data for England for the same ages for 2014-2019. Age-group specific serotype invasiveness was calculated and used with national IPD data to estimate carriage serotype distributions for adults aged 65+ years.

RESULTS:

In total 98 isolates (97 carriers) were identified from 1,631 adults aged 18+ years (age and sex standardized carriage prevalence 6.4%), with only three identified solely by PCR. Despite different carriage and IPD serotype distributions between adults and children, serotype invasiveness was highly correlated (R=0.9). Serotypes 3, 37 and 8 represented a higher proportion of adult carriage than expected from direct low-level transmission from children to adults. The predicted carriage serotype distributions for 65+ years aligned more closely with the carriage serotype distribution for young adults than young children.

CONCLUSIONS:

The nasal wash technique is highly sensitive; additional benefit of PCR is limited. Comparison of carriage serotype distributions suggests some serotypes may be circulating preferentially within these specific young adults. Our data suggest that for some serotypes carried by adults 65+ years, other adults may be an important reservoir for transmission. Age groups such as older children should also be considered.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido