Doughnut-shaped bimetallic Cu-Zn-MOF with peroxidase-like activity for colorimetric detection of glucose and antibacterial applications.
Talanta
; 279: 126544, 2024 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-39032456
ABSTRACT
Metal-organic frameworks (MOFs), especially bimetallic MOFs, have attracted widespread attention for simulating the structure and function of natural enzymes. In this study, different morphologies of bimetallic Cu-Zn-MOF with different peroxidase (POD)-like activities were prepared by simply controlling the molar ratio of Cu2+ and Zn2+. Among them, the doughnut-shaped Cu9-Zn1-MOF exhibited the largest POD-like activity. Cu9-Zn1-MOF was combined with glucose oxidase to construct a sensitive and selective glucose colorimetric biosensor with a linear detection range of 10-300 µM and a detection limit of 7.1 µm. Furthermore, Cu9-Zn1-MOF can efficiently convert hydrogen peroxide (H2O2) into hydroxyl radicals that effectively kill both gram-negative and gram-positive bacteria at low H2O2 level. The results of this study may promote the synthesis of bimetallic MOFs and broaden their applications in the biomedical field.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Colorimetria
/
Cobre
/
Estruturas Metalorgânicas
/
Glucose
/
Glucose Oxidase
/
Peróxido de Hidrogênio
/
Antibacterianos
Idioma:
En
Revista:
Talanta
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China