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A novel prognostic index for extranodal natural killer/T-cell lymphoma in the era of pegaspargase/L-asparaginase.
Shen, Ziyuan; Zhang, Xudong; Li, Yujie; Chen, Xicheng; Xing, Xing; Zhang, Hao; Ye, Jingjing; Wang, Ling; Jia, Tao; Zhu, Taigang; Miao, Yuqing; Wang, Chunling; Liu, Hui; Wang, Liang; Sang, Wei.
Afiliação
  • Shen Z; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
  • Zhang X; Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
  • Li Y; Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
  • Chen X; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
  • Xing X; Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
  • Zhang H; Department of Epidemiology & Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China.
  • Ye J; Department of Hematology, The Affiliated Hospital of Jining Medical University, Jining, Shandong, 272000, China.
  • Wang L; Department of Hematology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, China.
  • Jia T; Department of Hematology, Tai'an Central Hospital, Tai'an, Shandong, 271000, China.
  • Zhu T; Department of Hematology, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, 222061, China.
  • Miao Y; Department of Hematology, The General Hospital of Wanbei Coal-Electric Group, Suzhou, Anhui, 234011, China.
  • Wang C; Department of Hematology, Yancheng First People's Hospital, Yancheng, Jiangsu, 224001, China.
  • Liu H; Department of Hematology, The First People's Hospital of Huai'an, Huai'an, Jiangsu, 223300, China.
  • Wang L; Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, China.
  • Sang W; Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China.
Future Oncol ; : 1-11, 2024 Jul 23.
Article em En | MEDLINE | ID: mdl-39041580
ABSTRACT

Aim:

This multicenter retrospective study aimed to develop a novel prognostic system for extranodal natural killer/T-cell lymphoma (ENKTL) patients in the era of pegaspargase/L-asparaginase. Materials &

methods:

A total of 844 newly diagnosed ENKTL patients were included.

Results:

Multivariable analysis confirmed that Eastern Cooperative Oncology Group performance status, lactate dehydrogenase, Chinese Southwest Oncology Group and Asia Lymphoma Study Group ENKTL (CA) system, and albumin were independent prognostic factors. By rounding up the hazard ratios from four significant variables, a maximum of 7 points were assigned. The model of Huaihai Lymphoma Working Group-Natural killer/T-cell Lymphoma prognostic index (NPI) was identified with four risk groups and the 5-year overall survival was 88.2, 66.7, 54.3 and 30.5%, respectively.

Conclusion:

Huaihai Lymphoma Working Group-NPI provides a feasible stratification system for patients with ENKTL in the era of pegaspargase/L-asparaginase.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Future Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Future Oncol Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China