Genomic privacy preservation in genome-wide association studies: taxonomy, limitations, challenges, and vision.
Brief Bioinform
; 25(5)2024 Jul 25.
Article
em En
| MEDLINE
| ID: mdl-39073827
ABSTRACT
Genome-wide association studies (GWAS) serve as a crucial tool for identifying genetic factors associated with specific traits. However, ethical constraints prevent the direct exchange of genetic information, prompting the need for privacy preservation solutions. To address these issues, earlier works are based on cryptographic mechanisms such as homomorphic encryption, secure multi-party computing, and differential privacy. Very recently, federated learning has emerged as a promising solution for enabling secure and collaborative GWAS computations. This work provides an extensive overview of existing methods for GWAS privacy preserving, with the main focus on collaborative and distributed approaches. This survey provides a comprehensive analysis of the challenges faced by existing methods, their limitations, and insights into designing efficient solutions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Privacidade Genética
/
Estudo de Associação Genômica Ampla
Limite:
Humans
Idioma:
En
Revista:
Brief Bioinform
Assunto da revista:
BIOLOGIA
/
INFORMATICA MEDICA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Marrocos