Innate Immunity in Type 1 Diabetes.
Cold Spring Harb Perspect Med
; 2024 Jul 29.
Article
em En
| MEDLINE
| ID: mdl-39074873
ABSTRACT
Type 1 diabetes (T1D) results from the destruction of pancreatic ß cells by the immune system, to which both pancreatic ß-cell dysfunction and pathological activation of the immune system contribute. This paper is focused on understanding the modalities of this activation, and the genetic and environmental factors increasing its risk. Innate immunity has a critical role in the loss of self-tolerance and promotion of inflammation either directly using innate effector mechanisms or by providing activation signals to anti-islet adaptive autoimmunity. We provide an overview of various deleterious and protective roles of innate immunity in T1D inside pancreatic islets, regional lymph nodes, and distant locations such as the gut.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
França