Association between Pentosan Polysulfate and Subsequent Maculopathy: Insights from a Nationwide Population-Based Study in Korea.
Ophthalmology
; 2024 Jul 30.
Article
em En
| MEDLINE
| ID: mdl-39089371
ABSTRACT
PURPOSE:
To determine the association between pentosan polysulfate (PPS) use and the subsequent development of maculopathy in Asian population.DESIGN:
A nationwide population-based retrospective cohort study using the Health Insurance Review and Assessment Service database.PARTICIPANTS:
103,553 individuals in the PPS user group and 205,792 individuals in the PPS non-user group, all newly diagnosed with cystitis between 2009 and 2020.METHODS:
The association between PPS use and maculopathy was evaluated using a time dependent Cox proportional hazard model. Additionally, two sensitivity analyses were conducted by defining PPS users as individuals with an observation period over 6 months from the initial prescription or those with cumulative dose exceeding 9 g, employing the same analysis. MAIN OUTCOMEMEASURES:
The outcome measures included the hazard ratios (HR) representing the association between PPS use and maculopathy.RESULTS:
PPS use was associated with an increased risk of subsequent maculopathy in univariate (HR, 1.7; 95% confidence intervals [CI], 1.66-1.75) and multivariate analysis (HR, 1.34; 95% CI, 1.31-1.38). These results were also confirmed in two sensitivity analyses. The mean cumulative dose of PPS for the cohort was 37.2 ± 76.7 g.CONCLUSIONS:
In this nationwide cohort study involving an Asian population, individuals with cystitis using PPS exhibit an increased risk of developing subsequent maculopathy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Ophthalmology
Ano de publicação:
2024
Tipo de documento:
Article