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Uncovering the Role of Inflammation with Asphyxia in the Newborn.
Dhillon, Simerdeep K; Gressens, Pierre; Barks, John; Gunn, Alistair J.
Afiliação
  • Dhillon SK; Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand.
  • Gressens P; Université Paris Cité, NeuroDiderot, Inserm, F-75019 Paris, France.
  • Barks J; Department of Pediatrics and Communicable Diseases, The University of Michigan, 2018 MLB, Ann Arbor, MI 48109, USA.
  • Gunn AJ; Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Auckland 1023, New Zealand. Electronic address: aj.gunn@auckland.ac.nz.
Clin Perinatol ; 51(3): 551-564, 2024 Sep.
Article em En | MEDLINE | ID: mdl-39095095
ABSTRACT
The etiology of perinatal brain injury is multifactorial, but exposure to perinatal hypoxiaischemia (HI) is a major underlying factor. This review discusses the role of exposure to infection/inflammation in the evolution of HI brain injury, changes in immune responsiveness to subsequent inflammatory challenges after HI and modulation of neural outcomes with interaction between perinatal HI and inflammatory insults. The authors critically assess the clinical and preclinical evidence for the neuroprotective efficacy of therapeutic hypothermia and other anti-inflammatory treatments for inflammation-sensitized HI injury.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asfixia Neonatal / Hipóxia-Isquemia Encefálica / Hipotermia Induzida / Inflamação Limite: Animals / Humans / Newborn Idioma: En Revista: Clin Perinatol / Clin. perinatol / Clinics in perinatology Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Nova Zelândia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Asfixia Neonatal / Hipóxia-Isquemia Encefálica / Hipotermia Induzida / Inflamação Limite: Animals / Humans / Newborn Idioma: En Revista: Clin Perinatol / Clin. perinatol / Clinics in perinatology Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Nova Zelândia