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Characterizing white matter connectome abnormalities in patients with temporal lobe epilepsy using threshold-free network-based statistics.
Chu, Daniel Y; Imhoff-Smith, Theodore P; Nair, Veena A; Choi, Timothy; Adluru, Anusha; Garcia-Ramos, Camille; Dabbs, Kevin; Mathis, Jedidiah; Nencka, Andrew S; Conant, Lisa; Binder, Jeffrey R; Meyerand, Mary E; Alexander, Andrew L; Struck, Aaron F; Hermann, Bruce; Prabhakaran, Vivek; Adluru, Nagesh.
Afiliação
  • Chu DY; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Imhoff-Smith TP; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Nair VA; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Choi T; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Adluru A; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Garcia-Ramos C; Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Dabbs K; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Mathis J; Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, USA.
  • Nencka AS; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Conant L; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Binder JR; Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Meyerand ME; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Alexander AL; Department of Neurology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
  • Struck AF; Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin, USA.
  • Hermann B; Waisman Center, University of Wisconsin Madison, Madison, Wisconsin, USA.
  • Prabhakaran V; Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
  • Adluru N; Department of Neurology, William S. Middleton Veterans Hospital, Madison, Wisconsin, USA.
Brain Behav ; 14(8): e3643, 2024 Aug.
Article em En | MEDLINE | ID: mdl-39099405
ABSTRACT

INTRODUCTION:

Emerging evidence illustrates that temporal lobe epilepsy (TLE) involves network disruptions represented by hyperexcitability and other seizure-related neural plasticity. However, these associations are not well-characterized. Our study characterizes the whole brain white matter connectome abnormalities in TLE patients compared to healthy controls (HCs) from the prospective Epilepsy Connectome Project study. Furthermore, we assessed whether aberrant white matter connections are differentially related to cognitive impairment and a history of focal-to-bilateral tonic-clonic (FBTC) seizures.

METHODS:

Multi-shell connectome MRI data were preprocessed using the DESIGNER guidelines. The IIT Destrieux gray matter atlas was used to derive the 162 × 162 structural connectivity matrices (SCMs) using MRTrix3. ComBat data harmonization was applied to harmonize the SCMs from pre- and post-scanner upgrade acquisitions. Threshold-free network-based statistics were used for statistical analysis of the harmonized SCMs. Cognitive impairment status and FBTC seizure status were then correlated with these findings.

RESULTS:

We employed connectome measurements from 142 subjects, including 92 patients with TLE (36 males, mean age = 40.1 ± 11.7 years) and 50 HCs (25 males, mean age = 32.6 ± 10.2 years). Our analysis revealed overall significant decreases in cross-sectional area (CSA) of the white matter tract in TLE group compared to controls, indicating decreased white matter tract integrity and connectivity abnormalities in addition to apparent differences in graph theoretic measures of connectivity and network-based statistics. Focal and generalized cognitive impaired TLE patients showcased higher trend-level abnormalities in the white matter connectome via decreased CSA than those with no cognitive impairment. Patients with a positive FBTC seizure history also showed trend-level findings of association via decreased CSA.

CONCLUSIONS:

Widespread global aberrant white matter connectome changes were observed in TLE patients and characterized by seizure history and cognitive impairment, laying a foundation for future studies to expand on and validate the novel biomarkers and further elucidate TLE's impact on brain plasticity.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Epilepsia do Lobo Temporal / Conectoma / Substância Branca Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Behav Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Epilepsia do Lobo Temporal / Conectoma / Substância Branca Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Brain Behav Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos