The decline in murine splenic PHA and LPS responsiveness following serial transplantation of young and old bone marrow cells.
Mech Ageing Dev
; 32(2-3): 235-47, 1985 Nov.
Article
em En
| MEDLINE
| ID: mdl-3910972
ABSTRACT
An analysis was made of the ability of bone marrow cells derived from young (6 months) or old (28 months) murine (A X C57BL/6) donors to differentiate to B and T lymphocytes following serial bone marrow cell transplantations into groups of young syngeneic lethally irradiated recipients. Both number and mitogenic responsiveness of splenic B and T lymphocytes were recorded for recipients of young or old bone marrow cells 9 months following each serial transplant. The data suggests that lymphopoietic stem cells senescence in a manner analogous to that predicted by the clonal succession model of ageing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Medula Óssea
/
Linfócitos B
/
Ativação Linfocitária
/
Linfócitos T
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1985
Tipo de documento:
Article