Your browser doesn't support javascript.
loading
The need to diversify genomic studies: Insights from Andean highlanders and Amazonians.
Alvim, Isabela; Silva-Carvalho, Carolina; Mendes de Aquino, Marla; Borda, Victor; Sanchez, Cesar; Padilla, Carlos; Cáceres, Omar; Rezende-Diniz, Isabela; Saraiva-Duarte, Julia; Faria-Costa, Lucas; Santolalla, Meddly L; Rodrigues-Soares, Fernanda; Zolini, Camila; Llerena, Adrián; O'Connor, Timothy D; Gilman, Robert H; Guio, Heinner; Tarazona-Santos, Eduardo.
Afiliação
  • Alvim I; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; School of Natural Sciences, Massey University, Palmerston North, New Zealand; School of BioSciences, University of Melbourne, Melbourne, VIC, Australia; St. Vin
  • Silva-Carvalho C; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Mendes de Aquino M; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; The Centre for Applied Genomics and Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, ON, Canada.
  • Borda V; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; The University of Maryland-Institute for Health Computing, U
  • Sanchez C; Instituto Nacional de Salud, Lima, Peru.
  • Padilla C; Instituto Nacional de Salud, Lima, Peru.
  • Cáceres O; Instituto Nacional de Salud, Lima, Peru.
  • Rezende-Diniz I; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Saraiva-Duarte J; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Faria-Costa L; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Santolalla ML; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Emerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Rodrigues-Soares F; Department of Pathology, Genetic and Evolution, Biological and Natural Sciences Institute, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil.
  • Zolini C; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  • Llerena A; INUBE Extremadura Biosanitary Research Institute, Faculty of Medicine, University of Extremadura, Badajoz, Spain.
  • O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program in Health Equity and Population Health, University of Maryland School of Medicine, Baltimore, MD, USA; Program in Personalized Genomic Medicine, University of Maryland School of Medicine, Balt
  • Gilman RH; Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Guio H; Instituto Nacional de Salud, Lima, Peru; INBIOMEDIC Research and Technological Center, Lima, Peru; Universidad de Huanuco, Huanuco, Peru.
  • Tarazona-Santos E; Department of Genetics, Ecology and Evolution, Biological Sciences Institute, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Emerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru. Electr
Cell ; 2024 Jul 30.
Article em En | MEDLINE | ID: mdl-39121858
ABSTRACT
More globally diverse perspectives are needed in genomic studies and precision medicine practices on non-Europeans. Here, we illustrate this by discussing the distribution of clinically actionable genetic variants involved in drug response in Andean highlanders and Amazonians, considering their environment, history, genetic structure, and historical biases in the perception of biological diversity of Native Americans.
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Ano de publicação: 2024 Tipo de documento: Article