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Brain-charting autism and attention deficit hyperactivity disorder reveals distinct and overlapping neurobiology.
Bedford, Saashi A; Lai, Meng-Chuan; Lombardo, Michael V; Chakrabarti, Bhismadev; Ruigrok, Amber; Suckling, John; Anagnostou, Evdokia; Lerch, Jason P; Taylor, Margot; Nicolson, Rob; Stelios, Georgiades; Crosbie, Jennifer; Schachar, Russell; Kelley, Elizabeth; Jones, Jessica; Arnold, Paul D; Courchesne, Eric; Pierce, Karen; Eyler, Lisa T; Campbell, Kathleen; Barnes, Cynthia Carter; Seidlitz, Jakob; Alexander-Bloch, Aaron F; Bullmore, Edward T; Baron-Cohen, Simon; Bethlehem, Richard A I.
Afiliação
  • Bedford SA; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. Electronic address: ajb349@cam.ac.uk.
  • Lai MC; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK; The Margaret and Wallace McCain Centre for Child, Youth & Family Mental Health and Azrieli Adult Neurodevelopmental Centre, Campbell Family Mental Health Research Institute, Centre for Addiction an
  • Lombardo MV; Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems, Istituto Italiano di Tecnologia, Rovereto, Italy.
  • Chakrabarti B; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK; Centre for Autism, School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6ES, UK.
  • Ruigrok A; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK; Division of Psychology and Mental Health, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester.
  • Suckling J; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
  • Anagnostou E; Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada; Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
  • Lerch JP; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Mouse Imaging Centre, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences,
  • Taylor M; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Department of Diagnostic Imaging, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
  • Nicolson R; Department of Psychiatry, University of Western Ontario, London, Ontario, Canada.
  • Stelios G; McMaster University, Hamilton, Ontario, Canada.
  • Crosbie J; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Genetics & Genome Biology, The Hospital for Sick Children, Toronto,
  • Schachar R; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON M5T 1R8, Canada; Program in Neurosciences and Mental Health, Research Institute, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada; Genetics & Genome Biology, The Hospital for Sick Children, Toronto,
  • Kelley E; Department of Psychology, Queen's University, Kingston, ON K7L 3N6 Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6 Canada; Department of Psychiatry, Queen's University, Kingston, ON K7L 3N6 Canada.
  • Jones J; Department of Psychology, Queen's University, Kingston, ON K7L 3N6 Canada; Centre for Neuroscience Studies, Queen's University, Kingston, ON K7L 3N6 Canada; Department of Psychiatry, Queen's University, Kingston, ON K7L 3N6 Canada.
  • Arnold PD; The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • Courchesne E; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
  • Pierce K; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
  • Eyler LT; Department of Psychiatry, University of California San Diego, La Jolla, California, USA.
  • Campbell K; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
  • Barnes CC; Department of Neurosciences, University of California San Diego, La Jolla, California, USA.
  • Seidlitz J; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Me
  • Alexander-Bloch AF; Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Me
  • Bullmore ET; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
  • Baron-Cohen S; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK; Cambridge Lifetime Autism Spectrum Service (CLASS), Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
  • Bethlehem RAI; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 8AH, UK; Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK; Department of Psychology, University of Cambridge, Cambridge, UK.
Biol Psychiatry ; 2024 Aug 09.
Article em En | MEDLINE | ID: mdl-39128574
ABSTRACT

BACKGROUND:

Autism and attention deficit hyperactivity disorder (ADHD) are heterogeneous neurodevelopmental conditions with complex underlying neurobiology that is still poorly understood. Despite overlapping presentation and sex-biased prevalence, autism and ADHD are rarely studied together, and sex differences are often overlooked. Population modelling, often referred to as normative modelling, provides a unified framework for studying age-specific and sex-specific divergences in brain development.

METHODS:

Here we used population modelling and a large, multi-site neuroimaging dataset (N = 4255 after quality control) to characterise cortical anatomy associated with autism and ADHD, benchmarked against models of average brain development based on a sample of over 75,000 individuals. We also examined sex and age differences, relationship with autistic traits, and explored the co-occurrence of autism and ADHD (autism+ADHD).

RESULTS:

We observed robust neuroanatomical signatures of both autism and ADHD. Overall, autistic individuals showed greater cortical thickness and volume, that was localised to the superior temporal cortex, whereas individuals with ADHD showed more global increases in cortical thickness, but lower cortical volume and surface area across much of the cortex. The autism+ADHD group displayed a unique pattern of widespread increases in cortical thickness, and certain decreases in surface area. We also found evidence that sex modulates the neuroanatomy of autism but not ADHD, and an age-by-diagnosis interaction for ADHD only.

CONCLUSIONS:

These results indicate distinct cortical differences in autism and ADHD that are differentially impacted by age, sex, and potentially unique patterns related to their co-occurrence.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biol Psychiatry Ano de publicação: 2024 Tipo de documento: Article