Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src.
Science
; 227(4688): 761-3, 1985 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-3918346
ABSTRACT
The family of tyrosine-specific protein kinases includes proteins encoded by retroviral oncogenes as well as receptors for insulin and several growth factors. Antibodies to pp60src, the protein encoded by the src oncogene of Rous sarcoma virus (RSV), can specifically immunoprecipitate affinity-labeled insulin receptors from cultured human lymphocytes (IM-9 cells). This precipitation is specifically inhibited by the src gene product purified from RSV-transformed rat cells. These observations provide evidence that there is structural homology between the insulin receptors and pp60src.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Proteínas Quinases
/
Proteínas Virais
/
Receptor de Insulina
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1985
Tipo de documento:
Article