Using inflammatory biomarkers in early pregnancy to predict subsequent antenatal depression.
J Affect Disord
; 2024 Sep 02.
Article
em En
| MEDLINE
| ID: mdl-39233249
ABSTRACT
BACKGROUND:
Antenatal depression (AD) is one of the most common pregnancy complications. Recent studies indicated that immune responses during pregnancy may contribute to development of AD.OBJECTIVES:
This study aimed to identify possible inflammatory biomarkers in early pregnancy to predict maternal depressive symptoms before delivery.METHODS:
This case-control study was conducted within the Maternal and Infant Health (MI-Health) birth cohort (Beijing, China) and depressive symptoms were assessed by Zung Self-rating Depression Scale (SDS) in both second and third trimesters. By using immune multi-factors kits, we tested 26 inflammatory factors in the serum of 38 cases with antenatal depression symptoms in both trimesters (SDSâ¯≥â¯53) and 38 controls. Logistic regression was used to identify candidate biomarkers, and the predictive capabilities were evaluated by using Receiver Operator Characteristics (ROC) analysis.RESULTS:
The concentrations of ln(CCL24) (pâ¯=â¯0.020), IL-7 (pâ¯=â¯0.006) and IL-10 (pâ¯=â¯0.014) were higher in early pregnancy among women with depressive symptoms comparing to healthy controls. The difference remained statistically significant after adjusting for maternal age, education level, gestational diabetes mellitus, pre-pregnancy BMI and gestational weeks of blood sampling (OR(ln(CCL24))â¯=â¯4.625, OR(IL-7)â¯=â¯1.414, OR(IL-10)â¯=â¯1.151). In ROC analysis, ln(CCL24), IL-7, and IL-10 achieved discrimination for depressive symptoms antepartum, with the values of AUC estimated at 0.75.LIMITATIONS:
The sample size is limited, and the infectious disease infection records were not collected for control.CONCLUSION:
Higher levels of CCL24, IL-7 and IL-10 may indicate the higher risk of antenatal depression and are potential biomarkers indicating pathogenesis of antenatal depression.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Affect Disord
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China