Your browser doesn't support javascript.
loading
Risk factors associated with hospital mortality in non-surgical patients receiving extracorporeal membrane oxygenation and continuous renal replacement treatment: a retrospective analysis.
Hou, Jian; Wang, Cuiping; Wei, Ruibin; Zheng, Junteng; Liu, Zhen; Wang, Dayu; Li, Jianhao; Huang, Suiqing.
Afiliação
  • Hou J; Department of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Wang C; Department of Cardiothoracic ICU, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
  • Wei R; Department of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Zheng J; Department of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Liu Z; Department of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Wang D; Department of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Li J; Department of Cardiology, The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
  • Huang S; Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, GD, China.
Ren Fail ; 46(2): 2398711, 2024 Dec.
Article em En | MEDLINE | ID: mdl-39238266
ABSTRACT

OBJECTIVES:

The prognosis-predicting factors for non-surgical patients receiving continuous renal replacement therapy (CRRT) and extracorporeal membrane oxygenation (ECMO) remains limited. In this study, we aim to analyze prognosis-predicting factors in the non-surgical patients receiving these two therapies.

METHODS:

We retrospectively analyzed data from non-surgical patients with ECMO treatment from December 2013 until April 2023. Hospital mortality was primary endpoint of this study. The area under the curve and receiver operating characteristic curves were used to assess the sensitivity and specificity of mortality. The independent risk factors were identified by multivariate logistic regression. The prediction model was a nomogram, and decision curve analysis and the calibration plot were used to assess it. Using restricted cubic spline curves and Spearman correlation, the correlation analysis was performed.

RESULTS:

The model that incorporated CRRT duration and age surpassed the two variables alone in predicting hospital mortality in non-surgical patients with ECMO therapy (AUC value = 0.868, 95% CI = 0.779-0.956). Older age, CRRT implantation, and duration were independent risk factors for hospital mortality (all p < 0.05). The nomogram predicting outcomes model containing on CRRT implantation and duration was developed, and the consistency between the predicted probability and observed probability and clinical utility of the models were good. CRRT duration was negatively associated with hemoglobin concentration and positively associated with urea nitrogen and serum creatinine levels.

CONCLUSION:

Hospital mortality in non-surgical ECMO patients was found to be independently associated with older age, longer CRRT duration, and CRRT implantation.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigenação por Membrana Extracorpórea / Curva ROC / Mortalidade Hospitalar / Nomogramas / Terapia de Substituição Renal Contínua Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Assunto da revista: NEFROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxigenação por Membrana Extracorpórea / Curva ROC / Mortalidade Hospitalar / Nomogramas / Terapia de Substituição Renal Contínua Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ren Fail Assunto da revista: NEFROLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China