Association of cardiovascular disease risk with liver steatosis and fibrosis in people living with hiv in low- and middle-income countries.
AIDS
; 2024 Sep 12.
Article
em En
| MEDLINE
| ID: mdl-39264586
ABSTRACT
OBJECTIVE:
To understand the relationship between cardiovascular disease (CVD) risk and liver steatosis and fibrosis among people living with HIV (PLWH) ≥40âyears on antiretroviral therapy (ART) in low- and middle-income countries (LMIC).DESIGN:
We used cross-sectional behavioral and clinical data collected during study enrollment visits in 2020-2022 for the Sentinel Research Network of International epidemiology Databases to Evaluate AIDS (SRN of IeDEA).METHODS:
Ten-year CVD risk was calculated using 2019 World Health Organization non-laboratory and laboratory models. Transient elastography (TE) was used to assess liver disease. Presence of steatosis and significant fibrosis were defined by Controlled Attenuation Parameter (CAP) ≥248âdB/m and liver stiffness measurement (LSM) ≥7.1âkPa, respectively. Participants with viral hepatitis, hazardous alcohol consumption and unsuppressed HIV viral load were excluded from the analysis. Logistic regression was used to estimate odds ratios, adjusting for study site, CD4âT cell count, stavudine and didanosine exposure, and in models stratified by sex and geographic region.RESULTS:
There were 1,750 participants from nine LMIC. Median CVD risk was 3% for both non-laboratory and laboratory-based models. Adjusted odds ratios (ORs) for steatosis and significant fibrosis associated with laboratory CVD risk (≥10% vs. <5%) were ORâ=â1.83 (95% confidence interval(CI)â=â1.21-2.76; Pâ=â0.004) and ORâ=â1.62 (95% CIâ=â0.85-3.07; Pâ=â0.14), respectively. Associations of CVD risk with steatosis were stronger in males and among participants at study sites outside Africa.CONCLUSIONS:
Higher CVD risk was associated with steatosis but not with significant fibrosis in PLWH in our LMIC cohort.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2024
Tipo de documento:
Article