Hypertrophy of liver peroxisomes in type II and type IV hyperlipoproteinemia.
Atherosclerosis
; 59(3): 257-62, 1986 Mar.
Article
em En
| MEDLINE
| ID: mdl-3964346
ABSTRACT
A morphometric study on liver biopsies from patients with primary hyperlipoproteinemia (IIa n = 4, IIb n = 7, IV n = 7) and in controls (n = 7) was performed by light and electron microscopy. We found hypertrophy of peroxisomes in all subjects with hyperlipoproteinemia. As none of our patients had been given lipid-lowering drugs, this increase in volume seems to be due to hyperlipoproteinemia. Hypertrophy of peroxisomes in hyperlipoproteinemia may constitute a response of the hepatocyte to a disturbed metabolic state. Alterations of peroxisomes in hyperlipoproteinemia may thus occur prior to any lipid-lowering therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hiperlipoproteinemia Tipo II
/
Hiperlipoproteinemia Tipo IV
/
Fígado
/
Microcorpos
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Atherosclerosis
Ano de publicação:
1986
Tipo de documento:
Article