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Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker.
Clin Pharmacol Ther ; 26(6): 682-5, 1979 Dec.
Article em En | MEDLINE | ID: mdl-40725
The systemic bioavailability, elimination half-life (t1/2), and plasma concentration--response relationships of pamatolol, a relatively cardioselective beta adrenoceptor blocker, have been measured in healthy subjects. Pamatolol is rapidly and completely absorbed after oral dosing. Elimination t1/2 ranged from 2.9 to 4.6 hr after oral doses and from 2.2 to 5.6 hr after intravenous doses. There was a clear relationship between log plasma pamatolol concentration and sympathetic blockade assessed by reduction of exercise heart rate. Concentration-response curves were essentially identical after oral and intravenous doses. There is no evidence of a first-pass effect, nor is there any evidence of metabolite activity.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propanolaminas / Antagonistas Adrenérgicos beta Limite: Adolescent / Adult / Humans / Male Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 1979 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Propanolaminas / Antagonistas Adrenérgicos beta Limite: Adolescent / Adult / Humans / Male Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 1979 Tipo de documento: Article