QSAR in a series of muscarinic agents.
Farmaco Sci
; 34(8): 657-65, 1979 Aug.
Article
em En
| MEDLINE
| ID: mdl-467632
ABSTRACT
The results of a pharmacological investigation on a series of 3-substituted benzyltrimethylammonium salts possessing muscarinic activity are reported. Correlative analysis shows that the pharmacodynamic activity is a function of the hydrophobic-lipophilic and steric parameters associated with the substituents. In particular, it is revealed that a lipophilic pocket of limited size is present in the muscarinic receptor at an optimal distance from the electron--rich site with which the cationic termination interacts.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Parassimpatomiméticos
/
Compostos de Benzil
/
Compostos de Amônio Quaternário
Limite:
Animals
Idioma:
En
Revista:
Farmaco Sci
Ano de publicação:
1979
Tipo de documento:
Article