Suppression of in vitro antibody response by a serum factor (SAA) in experimentally induced amyloidosis.
J Exp Med
; 142(1): 236-41, 1975 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-50401
Serum from CBA/J mice made amyloidotic by chronic casein injections has been shown to suppress in vitro antibody response to SRBC. Similar suppression was also found with normal mouse serum but to a much lesser degree. This suppressive activity of both amyloidotic serum and normal serum was removed by absorption of the sera with antiserum to protein AA, the major constituent of casein-induced (secondary) amyloid fibrils. This antiserum to the amyloid fibril protein AA (mol wt 8,400 daltons) detects an immunologically cross-reacting serum alpha globulin (SAA) (mol wt approx. 100,000). It is postulated that the serum factor (SAA) is a regulator of antibody response and may be present in elevated amounts as the result of chronic antigenic stimulation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amiloidose
/
Formação de Anticorpos
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1975
Tipo de documento:
Article