Transplacental passage and fetal secretion of aldosterone.
J Clin Invest
; 49(7): 1389-93, 1970 Jul.
Article
em En
| MEDLINE
| ID: mdl-5432371
ABSTRACT
The transplacental passage and the production of aldosterone were studied in late pregnancy during a constant infusion of 1,2-aldosterone-(3)H to mothers at the time of elective cesarean section. It was found that, while maternal aldosterone crossed the placenta, there was a significant secretion of aldosterone by the fetus. The aldosterone concentration in fetal plasma was 2-12 times higher than that of the corresponding mothers. Pregnancy had no effect on the metabolic clearance rate of aldosterone, but it increased the rate of production of this steroid. However, the increments that we observed were smaller than those reported in previous reports. The discrepancy was probably due to differences in body posture, our subjects being supine for at least 10 hr at the time of study.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gravidez
/
Aldosterona
/
Feto
/
Troca Materno-Fetal
Limite:
Adolescent
/
Adult
/
Female
/
Humans
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
1970
Tipo de documento:
Article