Heritable fragile site on chromosome 16: probable localization of haptoglobin locus in man.
Science
; 170(3953): 85-7, 1970 Oct 02.
Article
em En
| MEDLINE
| ID: mdl-5452897
ABSTRACT
We have found recurrent chromosome breaks at a site (the "fragile site") on the long arm of chromosome 16. This site segregates in simple Mendelian dominant fashion in a large family. The distal portion of the chromosome sometimes shows selective endoreduplication. Preliminary linkage results reveal only 3 recombinants in 33 opportunities for recombination between the fragile site and the alpha locus of haptoglobin, an indication that the alpha-Hp gene is located near this region on chromosome 16.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Haptoglobinas
/
Aberrações Cromossômicas
/
Cromossomos Humanos 16-18
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
1970
Tipo de documento:
Article