Host-parasite relationships of Fasciola hepatica in the white mouse. VIII. Successful vaccination with culture incubate antigens and antigens from sonic disruption of immature worms.
J Parasitol
; 63(6): 1046-9, 1977 Dec.
Article
em En
| MEDLINE
| ID: mdl-592034
ABSTRACT
Mice were successfully vaccinated using culture incubate and sonicate antigens from 16-day-old flukes. Various injection schedules using the culture incubate antigen decreased challenge worm counts by 54 to 86%. The best results were achieved when the culture incubate was injected at 12 and 24 hr of incubation. Host mortality in the natural immunity controls ranged from 33 to 42%, and in the vaccinated animals from 12.5 to 25%. Functional antigens were present by 12 hr of incubation. A single immunizing injection with the sonicate antigen decreased challenge worm counts by 86%. Two immunizing injections with this antigen decreased challenge worm counts by 82%. However, the pathologic process in the liver was more severe than in animals that received a single injection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinação
/
Fasciola hepatica
/
Fasciolíase
/
Antígenos
Limite:
Animals
Idioma:
En
Revista:
J Parasitol
Ano de publicação:
1977
Tipo de documento:
Article