Effects of dihydroergotamine methanesulfonate on the microcirculation of the rat cremaster muscle.
Naunyn Schmiedebergs Arch Pharmacol
; 301(1): 83-5, 1977 Dec.
Article
em En
| MEDLINE
| ID: mdl-600323
ABSTRACT
Effects of dihydroergotamine on the microcirculation of the rat cremaster muscle were investigated microscopically using colour photographic technique. 1. Dihydroergotamine 10(-4) g/ml constricted arterioles of the rat cremaster. 2. Dihydroergotamine 10(-4) g/ml produced a significant contraction of venules. 3. Dihydroergotamine 10(-4) g/ml markedly inhibited the contractile response of noradrenaline 10(-6) g/ml on arterioles of the rat cremaster. The results suggest that dihydroergotamine has an appreciable vasoconstrictive action, especially upon venules, and that dihydroergotamine also has an adrenergic alpha-receptor blocking action. By means of highly sensitive negative colour film we obtained a satisfactory photograph of the rat cremaster's circulation.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Di-Hidroergotamina
/
Músculos
Limite:
Animals
Idioma:
En
Revista:
Naunyn Schmiedebergs Arch Pharmacol
Ano de publicação:
1977
Tipo de documento:
Article