p-Chlorophenylalanine-induced chemical manifestations of phenylketonuria in rats.
Science
; 156(3772): 248-50, 1967 Apr 14.
Article
em En
| MEDLINE
| ID: mdl-6067026
ABSTRACT
p-Chlorophenylalanine, a potent inhibitor of phenylalanine hydroxylase in vivo, has been used to simulate phenylketonuria in rats. This inhibitor, when administered with phenylalanine, produces marked elevation of blood and tissue phenylalanine without an increase in tyrosine. Disproportionate ratios of phenylalanine to tyrosine are characteristic of phenylketonuria in humans. The use of p-chlorophenylalanine permits the production of this characteristics amino acid imbalance in experimental animals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Fenilcetonúrias
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1967
Tipo de documento:
Article