FMRFamide inhibition of a molluscan heart is accompanied by increases in cyclic AMP.
Neuropeptides
; 3(1): 19-27, 1982 Oct.
Article
em En
| MEDLINE
| ID: mdl-6185875
ABSTRACT
The molluscan neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) inhibits the beat of isolated ventricles of the freshwater clam Lampsilis claibornensis. The decline in frequency and diastolic tone precedes the dose- and time-dependent increase in cAMP also produced by the peptide. Phosphodiesterase inhibitors (theophylline, 3-isobutyl-1-methylxanthine) and cAMP analogs also inhibit Lampsilis hearts, but only at high doses (10(-5)-10(-3)M). Again, the inhibition by theophylline is accompanied by a rise in cAMP. Nevertheless, the delayed increase in cAMP levels following FMRFamide treatment may suggest that cAMP is not mediating the onset of FMRFamide cardioinhibition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
AMP Cíclico
/
Moluscos
Limite:
Animals
Idioma:
En
Revista:
Neuropeptides
Ano de publicação:
1982
Tipo de documento:
Article