Induction of pituitary lactotrope differentiation by luteinizing hormone alpha subunit.
Science
; 226(4674): 566-8, 1984 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-6208610
ABSTRACT
Addition of gonadotropin releasing hormone to cultures of fetal rat pituitary induced differentiation of lactotropes as revealed by immunocytochemistry. Antiserum to luteinizing hormone (LH) (recognizing native LH), but not antiserum to LH-beta (recognizing both native LH and its beta subunit), inhibited this induction. Further addition of highly purified LH-alpha subunit in culture medium also induced lactotrope differentiation. Thus, the alpha subunit may have a specific biological activity of its own with probable practical use in clinical investigations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Hipófise
/
Hormônios Adeno-Hipofisários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1984
Tipo de documento:
Article