Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles.
Science
; 199(4328): 534-6, 1978 Feb 03.
Article
em En
| MEDLINE
| ID: mdl-622552
ABSTRACT
The protease inhibitor leupeptin decreases protein degradation in rat skeletal and cardiac muscle incubated in vitro, while protein synthesis remains unaltered. Leupeptin also lowers protein breakdown in denervated rat muscles and affected muscles from mice with hereditary muscular dystrophy. Leupeptin may thus be useful in retarding tissue atrophy. Since homogenates of leupeptin-treated muscles had decreased cathepsin B activity, this lysosomal protease may play a role in protein turnover in normal and diseased muscles.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Peptídeo Hidrolases
/
Leupeptinas
/
Proteínas Musculares
/
Músculos
/
Distrofia Muscular Animal
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1978
Tipo de documento:
Article